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TMG w/Folinic Acid & Methyl B-12 - Hypoallergenic - 200 ct

TMG w/Folinic Acid & Methyl B-12 - Hypoallergenic - 200 ct

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Product #: 0295-200
Size: 200 Capsules
Product Form: Vegetarian Capsules
Product Class: DMG & TMG
Primary Use: Supports the methylation pathway and seratonin levels.


Kirkman® offers 175 mg Trimethylglycine (TMG) in capsules with folinic acid and vitamin B-12.  This is a hypoallergenic formulation, specially designed for individuals with special requirements and sensitivities.

Kirkman’s TMG is derived from beets, which is the commercially available source.  TMG is dimethylglycine (DMG) with one more methyl group.  The chemical structure of TMG is a glycine molecule holding onto three methyl groups.  Like DMG, TMG is considered a "methyl donor" or “methyl bank."  The additional methyl group makes TMG a more active methyl donor than DMG, which provides a benefit to some individuals.  TMG can support the formation of methionine by methylating homocysteine.  Some of this methionine eventually is converted into SAMe (S-adenosylmethionine), which can help maintain healthy serotonin levels in the body, thus supporting mood and a feeling of well-being.  As with DMG, TMG plus a coenzyme of riboflavin supplies methyl groups that attach to folic acid to form methylene tetrahydrofolate, an important component of many biochemical processes in the body including cellular perception and response.

Folic acid intake and levels in the body must be adequate for TMG to work biochemically. To be active in the body, folic acid needs to be reduced twice by folate reductase enzymes, then converted to tetrahydrofolate, after which a methyl group is added to the tetrahydrofolate.  In some individuals, the use of natural folinic acid may be more beneficial than folic acid, because folinic acid already has attached four hydrogen atoms and one methyl group, thereby shortcutting the complicated biochemical processes that assist purine and nucleotide synthesis, which are so important in cell perception and response.  For that reason, some doctors are recommending TMG with folinic acid instead of the folic acid form of folate. 

Vitamin B-12 has also been included in this formulation because  folic acid can sometimes mask low vitamin B-12 levels in the body.  In addition vitamin B-12 works synergistically with folic acid.  The most active form of vitamin B-12 in folate chemistry is methylcobalamin, and Kirkman® utilizes this form of B-12 in this product, which may assist methionine metabolism, methylation, and folate chemistry.

Sugar, Starch, Soy, Wheat, Casein, Gluten, Milk, Corn, Preservatives, Yeast, Gelatin, Flavorings, Colorings
Trimethylglycine, Microcrystalline Cellulose, Magnesium Stearate (Vegetable), Silicon Dioxide, Di-Calcium Phosphate, Methylcobalamin, Calcium Folinate, Plant Cellulose Capsule.



These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.